While conventional inflammatory biomarkers such as the neutrophil-lymphocyte ratio (NLR), interleukin-8 (IL-8), interleukin-10 (IL-10), and high-sensitivity C-reactive protein (hs-CRP) demonstrate predictive value for CAD detection, their clinical utility is limited by environmental susceptibility and instability. Here, CXCL8 is linked to coronary artery disorder.