Levels of DBIL [5 (4–7) vs. 3 (2–4) μmol/L, p < 0.001], TBIL [21 (16–28) vs. 16 (13–20) μmol/L, p < 0.001], BNP [403 (246–575) vs. 210 (98–368) pg/mL, p < 0.001], and γ-GGT [30.5 (20–55) vs. 42 (26–66) μ/L, p < 0.001] were significantly higher in AF patients with moderate-to-severe TR compared with those without. The gene discussed is NPPB; the disease is atrial fibrillation.