The Fisher-Freeman-Halton exact test for CD4 cell count and prognosis of 23 included patients with HIV-related cryptococcal meningitis revealed that the distribution of CD4 counts showed a significant immunosuppression state: 60.9% (14/23) of patients with CD4 <50 cells/μL, 30.4% (7/23) at 50–200 cells/μL and only 8.7% (2/23) >200 cells/μL. Here, CD4 is linked to Cryptococcal meningitis.