TNF and fungal infectious disease: Moreover, the significant contribution of IFN-γ and TNF-α in CSF PC2’, together with the observation that CSF IL-10 levels declined markedly only at day 14 of antifungal therapy, whereas plasma IL-10 levels decreased significantly by day 7, supports the hypothesis of “tissue-specific immune heterogeneity in fungal infections” proposed by Romani, suggests that the CNS microenvironment may be partially resistant to systemic immunosuppression (Romani, 2011).