This difference may be related to the unique immune microenvironment of HIV infection, and IL-8 may recruit activated lymphocytes through CXCR1/CXCR2 signaling in advanced AIDS patients (Baggiolini et al., 1989; Lane et al., 1999; Kedzierska et al., 2003). This evidence concerns the gene CXCR1 and HIV infectious disease.