Moreover, while prior research has identified correlations between the PI3K/AKT/NF-κB pathway and antifungal inflammatory immune responses, the crucial role of PFKFB3 in FK inflammation through PI3K/AKT/NF-κB-dependent mechanisms, particularly considering various upstream targets and infections by different fungal strains, necessitates further exploration. Here, PFKFB3 is linked to infection.