Blautia, which upregulates intestinal regulatory T cells and promotes biotransformation (Liu et al., 2021), and Ruminococcus, which promotes immune activation and the production of cytokines like TNF-α, suggest that immune dysregulation driven by abnormal gut microbiota may play a key role in psoriasis pathogenesis (Henke et al., 2019). The gene discussed is TNF; the disease is psoriasis.