TNF and Alzheimer disease: Within the AD group, correlations were observed in EOAD with TNF (r = 0.480; q = 0.040; CI 0.06 to 0.76) LRP1 (r = 0.785; q < 0.0001; CI 0.53 to 0.91) and MMP9 (r = 0.805; q < 0.0001; CI 0.56 to 0.92), but not in LOAD (Table 2).