CSF3 and neutropenia: During treatment, patients received transfusion support according to institutional protocols: packed red blood cell transfusions for hemoglobin <7 g/dL, platelet transfusions for platelet counts <20,000/mm3, and granulocyte colony-stimulating factor for persistent moderate/severe neutropenia or neutropenia requiring treatment interruption (neutrophil count <500/mm3 for >2 weeks).