EDN1 and colorectal carcinoma: Clinically, high EDN1 expression correlated with reduced overall survival (OS; HR = 1.94e+00, p = 1.1e−02) (Fig. 1C) and progression-free survival (PFS; HR = 2.97e+00, p = 8.34e−04) (Fig. 1D) in CRC patients.