Notably, p-YAP Tyr357 levels were markedly elevated in EDN1-high CRC cell lines (LOVO and HT29), whereas minimal induction was observed in EDN1-low lines (HCT8 and SW480) (Fig. 5B), further supporting the association between EDN1 expression and YAP activation. The gene discussed is EDN1; the disease is colorectal carcinoma.