Different subpopulations of DNA methylation patterns in adult gliomas revealed that RFX1 in low-grade astrocytes, oligodendrocytes, and early-onset glioblastoid tumors showed a highly methylated pattern that promoted the expression of the methyltransferase enhancer of zeste human homologue 2 and was associated with improved survival [51]. Here, RFX1 is linked to glioma.