These early successes in inhibiting BRD4 not only serve as a proof of concept for the inhibition of proteins involved in transcription but can also have direct relevance in down-regulation of lineage-defining factors and networks of transcription factors, such as ELF3 in gastric cancer, which depend more heavily on BRD4 and super-enhancer-mediated transcription [59]. This evidence concerns the gene BRD4 and gastric cancer.