CDKN2A and gastric cancer: Other frequently deleted genes in gastric cancer, PRKN (encoding for ubiquitin ligase Parkin, also located at a fragile site), and for CDK inhibitor CDKN2A, were also more frequently observed in the up-regulated group, without reaching significance (Student’s t-test p = 0.13 and 0.21, respectively, Fig. 9).