About 80% of cases in the group with ELF3/HNF4A up-regulation had an Aneuploidy score (AS) above 4% and 87% of cases had a Fraction of Genome Altered (FGA) index above 0.1, consistent with the high prevalence of CIN in the group (Table 3). The gene discussed is HNF4A; the disease is cervical squamous intraepithelial neoplasia.