The chromosomal instability (CIN) high group of gastric cancers displays mutations in the gene encoding for the p53 tumor suppressor and frequent mutations in receptor tyrosine kinase pathways, while Epstein-Barr virus (EBV) associated cancers express the viral product EBV encoded RNA (EBER) and present frequent mutations in PI3K kinase catalytic subunit PIK3CA. This evidence concerns the gene NTRK1 and neoplasm.