WWOX and cancer: Regarding copy number alterations, the most commonly deleted locus in gastric adenocarcinomas at 16q23.1, a fragile site encoding for WW domain containing oxidoreductase WWOX, was twice as frequently deleted in ELF3/HNF4A up-regulated cancers (42.9%) compared with ELF3/HNF4A non-up-regulated gastric cancers (21.4%, Student’s t-test p = 0.04, Fig. 9).