HNF4A and neoplasm: In contrast significant differences between the groups were observed in tumor histology and tumor grade, with the group without ELF3/HNF4A up-regulation displaying more frequently diffuse histology (40.5% vs. 4.1% in the group with ELF3/HNF4A up-regulation, χ2 test p = 0.00003) and high grade (88.1% vs. 32.7% in the group with ELF3/HNF4A up-regulation, χ2 test p = 0.00001, Table 2).