The chromosomal instability (CIN) high group of gastric cancers displays mutations in the gene encoding for the p53 tumor suppressor and frequent mutations in receptor tyrosine kinase pathways, while Epstein-Barr virus (EBV) associated cancers express the viral product EBV encoded RNA (EBER) and present frequent mutations in PI3K kinase catalytic subunit PIK3CA. Here, TP53 is linked to cancer.