To address these limitations and bridge current knowledge gaps, future studies should focus on elucidating the broader regulatory network of HOXA10-AS, including its potential interactions with additional hub genes, miRNAs, or signaling pathways, such as Wnt/β-catenin or PI3K-AKT, to comprehensively define its role in glioblastoma progression. Here, AKT1 is linked to glioblastoma.