CASP3 and central nervous system cancer: MnSOD overexpression was documented to inhibit the proliferation of glioma cells [54,55], supporting the notion that antioxidant therapies are associated with increased expression of MnSOD and catalase [56], including SOD supplementation linked with upregulated caspase-3 [57], sensitize cells to oxidative stress-mediated apoptosis, and thus serve as potential anticancer strategies.