Fig. 1A illustrates that compared to normal tissues, TROP-2 expression is significantly higher in PSCC tissues. Both WB and qPCR assays confirmed elevated TROP-2 expression in tumor tissues (Fig. 1B,C). Additionally, we detected its expression in five PSCC cancer cell lines and normal squamous epithelium, and the results showed the same trend (Fig. 1D,E). Here, TACSTD2 is linked to cancer.