FGFR4 and head and neck squamous cell carcinoma: RNA Interference (RNAi) screening coupled with organoid models identified Fibroblast Growth Factor Receptor 4 (FGFR4) as a key target in HPV-negative HNSCC, inhibition of which reverses EMT—specifically, in sensitive cells, it leads to significant downregulation of mesenchymal markers such as Vimentin and upregulation of epithelial markers—and improves radiosensitivity [71].