G31P inhibits AKT and ERK phosphorylation by directly blocking CXCR1/2 signaling in tumor cells and indirectly decreases CXCL1/8 driven paracrine activation, consistent with evidence that CXCR1/2 blockade inhibits PI3K/AKT signaling in multiple cancers. The gene discussed is CXCL1; the disease is neoplasm.