Tumor-specific promoters (TSPs) and logic-gated circuits (e.g., Lokon Pharma Adenovirus 703 (LOAd703) adenovirus driving IL-2 and 4-1BB Ligand (4-1BBL) via Δ24 E1A-TSP) ensuring spatially restricted transgene activation [92]. Here, DHTKD1 is linked to neoplasm.