Recent strategies involving the expression of C-C motif chemokine ligand 5 (CCL5) and C-X-C motif chemokine ligand 10 (CXCL10) in engineered OVs can selectively recruit effector T cells and physically segregate regulatory T cell-myeloid-derived suppressor cell (Treg-MDSC) clusters, offering innovative approaches for tumor microenvironmental remodeling [114–116]. This evidence concerns the gene CCL5 and neoplasm.