For instance, vaccinia virus cf-33-hnis-antipd-l1 expressing anti-PD-L1 monoclonal antibody can significantly reduce the tumor burden and prolong the survival time of colorectal cancer model by locally blocking PD-1/PD-L1 axis, activating CD8+ T cells and reducing myeloid derived suppressor cell infiltration [68,69]. Here, CD274 is linked to colorectal cancer.