Genetically engineered viruses (e.g., adenoviruses carrying C-X-C motif chemokine ligand 10 (CXCL10) or poxviruses expressing TGF β inhibitors) can synergistically activate pattern recognition receptors, amplify IFN-I effects, and recruit cxcr3+immune cells to enhance anti-tumor response [14,42,43]. Here, CXCR3 is linked to neoplasm.