TNF and neoplasm: For instance, the measles virus variant MeVac FmIL-12, engineered to encode an IL-12 fusion protein, induces complete tumor regression in 90% of immunocompetent MC38cea mouse models through orchestrated Th1-directed immune responses, upregulation of IFN-γ and TNF-α, and coordinated activation of NK and CD8+ T cell populations [160].