Menotti’s team inserted interleukin-13 (IL-13) or single chain Fv (scFv) into HSV glycoprotein gD to promote the recognition of tumor antigens (e.g., her2/egfr), thereby increasing the specificity of virus infection by 4–6 times, which indicates that this specificity can be enhanced through genetic engineering strategies [99]. This evidence concerns the gene ERBB2 and neoplasm.