Alzarea et al. [59] reported that lipopolysaccharide (LPS)‐induced neuroinflammation and depression in mice are mitigated by peroxisome proliferator‐activated receptor α (PPAR‐α) agonism, with PPAR‐α suppressing NF‐κB expression and exerting antidepressant and procognitive effects that can be reversed by PPAR‐α antagonism. The gene discussed is PPARA; the disease is major depressive disorder.