A clinical study by Savitz et al. [60] found that cytomegalovirus infection exacerbates depressive symptoms in patients with MDD by enhancing NF‐κB activity, with reductions in viral antibody titers or cluster of differentiation (CD) 8+ T cell activity correlating with reduced depressive symptomatology and NF‐κB signaling. The gene discussed is NFKB1; the disease is cytomegalovirus infection.