Zhang et al. [149] established that paenol reduces microglial proinflammatory cytokine (IL‐6 and TNF‐α) expression in LPS‐induced depression models via hypoxia‐inducible factor 1, alpha subunit (HIF‐1α) pathway modulation, significantly attenuating depressive behaviors. The gene discussed is HIF1A; the disease is depressive symptom measurement.