PIK3CA and Hyperglycemia: While clinical trial results to support specific nutritional interventions in patients receiving PI3K inhibitors are currently lacking, further clarity on nutritional management strategies may be provided in several upcoming study reports, including NCT05090358 looking at the ketogenic diet, low carbohydrate diet and canagliflozin (SGLT2i) impact on alpesilib-induced hyperglycemia in a three-arm design (128).