CXCL9 and acute respiratory distress syndrome: Under these conditions, the CXCL9/10–CXCR3 axis is consistently associated with the recruitment of activated T cells and macrophages, type 1 immune polarization, and sustained parenchymal inflammation, suggesting that these chemokines act as general amplifiers of pulmonary inflammation, promoting tissue damage, rather than as specific causal triggers of ARDS.