Under these conditions, the CXCL9/10–CXCR3 axis is consistently associated with the recruitment of activated T cells and macrophages, type 1 immune polarization, and sustained parenchymal inflammation, suggesting that these chemokines act as general amplifiers of pulmonary inflammation, promoting tissue damage, rather than as specific causal triggers of ARDS. This evidence concerns the gene CXCR3 and acute respiratory distress syndrome.