NFE2L2 and Friedreich ataxia: First, mechanistic work should integrate spatial metabolomics and mitochondrial proteomics to map ferroptosis pathways in cerebellar, spinal, and cardiac tissues from FRDA patients, with emphasis on the interaction between the iron–sulfur cluster synthesis complex (NFS1–ISCU–ISD11) and ferroptosis-related molecules (GPX4, Nrf2).