CD4 and cancer: On the basis of the expression of canonical marker genes, the 22 clusters were further annotated into 12 cell types: B cells, plasma cells, CD4+ T cells, CD8+ T cells, NK cells, NK-T cells, monocytes, dendritic cells, macrophages, fibroblasts, endothelial cells, and epithelial/cancer cells (Figures 11D, E).