SHH and cancer: We visualized the distribution of 12 core genes (excluding NMRAL2P) across different cell types (Figures 12A, B), revealing that CDC25C, SHH, ASPG, WDR72, and NOS2 were expressed mainly in epithelial/cancer cells; DAPK1, ANKRD22, and SERPINA1 were expressed primarily in epithelial/cancer cells, monocytes, and macrophages; and SEZ6L2 and ANGPTL4 were expressed predominantly in epithelial/cancer cells and fibroblasts.