Underexplored epigenetic and long-term regulatory mechanisms: Epigenetic regulation of ferroptosis in AKI-to-CKD transition is largely limited to individual molecules (e.g., miRNAs targeting GPX4), with no comprehensive understanding of epigenetic landscapes (e.g., long non-coding RNAs, histone modifications, and DNA methylation) that persistently modulate ferroptosis-related genes during the chronic phase. This evidence concerns the gene GPX4 and acute kidney injury.