Additionally, the impact of host factors (e.g., age, genetics, and comorbidities like hypertension or diabetes) on ferroptosis sensitivity in AKI-to-CKD transition is understudied; whether genetic polymorphisms in ferroptosis regulators (e.g., SLC7A11 and ACSL4) contribute to inter-individual differences in progression risk remains unknown. This evidence concerns the gene ACSL4 and acute kidney injury.