GPX4 and renal carcinoma: Icariin II (ICS II), a flavonoid from Epimedium koreanum, triggers ferroptosis in renal carcinoma by downregulating GPX4 in a p53-independent manner and upregulating miR-324-3p, which suppresses GPX4 expression, leading to iron accumulation, lipid peroxidation, and GSH depletion (234).