First, the context-dependent regulatory switch that dictates whether p53 promotes or inhibits ferroptosis remains undefined; how cellular microenvironments (e.g., nutrient availability and oxidative stress levels), tissue types, or cancer subtypes toggle p53’s interaction with target genes (SLC7A11/SSAT1 vs. DPP4) has not been systematically elucidated. The gene discussed is TP53; the disease is cancer.