1) Mechanistic gaps in non-classical pathways and tumor microenvironment (TME) crosstalk: Current research centers on classical ferroptosis regulators (GPX4, SLC7A11, and ACSL4) but overlooks the role of non-classical ferroptosis suppressors (FSP1, DHODH, and GCH1/BH4) in RCC. Here, AIFM2 is linked to renal cell carcinoma.