Differential expression of apoptosis-inducing factor mitochondria-associated 2 (AIFM2/FSP1; Figure 7E), CDGSH iron sulfur domain-containing protein 1 (CISD1; Figure 7F), Kelch-like ECH-associated protein 1 (KEAP1; Figure 7G), and thioredoxin (TXN; Figure 7H) reveals heterogeneous alterations in ferroptosis resistance capacity of renal cells in AKD and CKD across multiple nodes of ferroptosis-suppressing pathways, including iron metabolism and redox homeostasis. The gene discussed is AIFM2; the disease is chronic kidney disease.