Its downregulation in DN kidneys correlates with injury (121), whereas its restoration—by vitexin (123), ginkgolide B (via inhibition of GPX4 ubiquitination) (121), platycodin D (125), or Buyang Huanwu Decoction (168)—robustly inhibits ferroptosis. The gene discussed is GPX4; the disease is liver dysplastic nodule.