Similarly, Buyang Huanwu Decoction reduces DN murine renal histopathology by upregulating SLC7A11 and GPX4 to restrain ferroptosis (180); Shenqi Dihuang Decoction attenuates high glucose-induced ferroptosis in HK-2 cells by activating the Nrf2/HO-1/GPX4 axis, lowering Fe2+ and ROS, and mitigating peroxidative damage (181). The gene discussed is HMOX1; the disease is liver dysplastic nodule.