Acyl-CoA synthetase long-chain family member 1 (ACSL1; Figure 6F), heme oxygenase-1 (HMOX1; Figure 6G), and nuclear receptor coactivator 4 (NCOA4; Figure 6H) collectively reveal differential activation patterns of ferroptosis-promoting pathways in AKD and CKD renal cells from multiple dimensions—lipid biosynthesis, heme degradation (oxidative stress amplification), and ferritinophagy regulation, respectively. The gene discussed is HMOX1; the disease is chronic kidney disease.