In dengue virus infection, the ancestral alleles HLA-DRB1*04:01 and HLA-DRB1*15:01 have shown greater resistance to dengue virus infection, recognizing a larger number of epitopes and generating a more efficient IFN-γ response compared with other alleles and closely related allelic variants, such as *04:03 and *15:02 (38). The gene discussed is HLA-DRB1; the disease is dengue disease.