Similarly, in multiple sclerosis the risk haplotype HLA-DRB1*15:01 (DR2) is associated with impaired immune control of EBV, hindering recognition and elimination of EBV-infected cells (53) and, together with EBV immune-evasion factors (vIL-10, BNLF2a) that reduce antigen presentation (62), promotes viral persistence and chronic antigenic stimulation that can trigger reactivity against myelin (295, 296). This evidence concerns the gene HLA-DRB1 and multiple sclerosis.