Numerous genes within the epigenome are also associated with vascular inflammation: the PTX3 gene plays a crucial regulatory role in inflammation (92); ANCA-associated vasculitis correlates with the HLA-DPB1 gene; giant cell arteritis correlates with the HLA-B52 gene; NR1H3 is a candidate gene regulating AAA formation ... Epigenomic studies reveal that subclinical atherosclerosis mediated by systemic inflammation is highly correlated with accelerated epigenetic aging (93). This evidence concerns the gene NR1H3 and anti-neutrophil cytoplasmic antibody-associated vasculitis.