Suberoylanilide hydroxamic acid (SAHA) is a type of HDAC inhibitor that exerts anti-inflammatory effects in endothelial cells via a Kruppel-like factor 2 (KLF2)-dependent mechanism (80); The specific HDAC inhibitor Trichostatin A (TSA) mediates anti-inflammatory properties to alleviate AS through the key mediator PPARγ (Peroxisome proliferator-activated receptor gamma) (81). The gene discussed is KLF2; the disease is aortic stenosis.