PTX3 and inflammation: Numerous genes within the epigenome are also associated with vascular inflammation: the PTX3 gene plays a crucial regulatory role in inflammation (92); ANCA-associated vasculitis correlates with the HLA-DPB1 gene; giant cell arteritis correlates with the HLA-B52 gene; NR1H3 is a candidate gene regulating AAA formation ... Epigenomic studies reveal that subclinical atherosclerosis mediated by systemic inflammation is highly correlated with accelerated epigenetic aging (93).