The addition of immunofixation electrophoresis (IFE) allows us to quantify the M-protein and establish polyclonal immunoglobulin levels (178), while serum-free light chain (sFLC) measurement is useful to identify non-secretory myeloma and in the diagnostic approach to hypogammaglobulinemia (179, 180). The gene discussed is MYOM2; the disease is plasma cell myeloma.