demonstrated that silencing the TLR4/SIRT2 pathway, achieved in TNBC using Sirtinol-conjugated nanomicelles, resulted in increased oxidative stress, inhibition of IL-6 secretion by tumor-associated macrophages, and blockade of cancer cell migration, effectively counteracting the metastatic potential induced by doxorubicin (204). The gene discussed is IL6; the disease is neoplasm.