Activation of the Heterogeneous Nuclear Ribonucleoprotein D (hnRNP D)/PPARG Coactivator 1 Alpha (PGC-1α) module enhances angiogenesis and invasion, whereas FOXO1-driven acetylation following SIRT1 loss suppresses tumor growth and promotes apoptosis (88, 90). The gene discussed is PPARGC1A; the disease is neoplasm.