The case presented a 58‐year‐old Hispanic woman with HIV, managed on bictegravir/emtricitabine/tenofovir alafenamide with an undetectable viral load and a CD4 count of 31, who experienced cyclical fevers accompanied by transaminitis, hyperbilirubinemia, and hyponatremia. Here, CD4 is linked to Hyponatremia.