For instance, miR-486-3p is downregulated in sorafenib-resistant HCC cell lines such as SK-Hep-1-SR, HepG2-SR, and Huh7-SR, and targets key mediators such as EGFR and fibroblast growth factor receptor-4 (FGFR4)[55]. Here, FGFR4 is linked to hepatocellular carcinoma.