POU5F1 and hepatocellular carcinoma: We have also investigated the impact of TFDP1 and miR-1-3p on HCC progression and observed that both depletion of TFDP1 and restoration of miR-1-3p suppressed cell proliferation and reduced expression of EMT (N-Cadherin, Vimentin) and stemness signatures (Oct4, Sox2 and Nanog) in HBV-monomer transfected Huh7 cells (Figures 5a–f).