1. Interacts with RNA-binding protein TDP-43 to induce its mitochondrial accumulation, causing mitochondrial DNA leakage, activating cGAS-STING pathway, and producing anti-viral immune response;2. Induces immunogenic cell death in lung adenocarcinoma cells, releases DAMPs, and promotes cross-activation of T cells by dendritic cells. Here, CGAS is linked to lung adenocarcinoma.