This, in turn, promotes the priming and activation of CD8+ T cells, strengthening antitumor adaptive immunity (Figure 3) Notably, cEMSY expression is downregulated in NSCLC tissues, and its restoration in preclinical models significantly inhibits tumor growth by reactivating the cGAS–STING pathway—highlighting its potential as a therapeutic target. This evidence concerns the gene STING1 and neoplasm.