Multiple injury models, including optic nerve crush, traumatic brain injury, ischemic stroke, and hyperglycemia-induced neurotoxicity, have consistently demonstrated NRN1’s ability to reduce neuronal apoptosis (Sharma et al., 2015; Liu et al., 2018; Yan et al., 2018; Xu et al., 2023). Here, NRN1 is linked to ischemic stroke.