Similarly, upregulation of the IL-5 receptor subunit IL5RA was found specifically expressed in GATA2+ LSCs of= patients with t(8;21) AML using single-cell RNA sequencing, which along with vascular endothelial growth factor A (VEGFA)/VEGF receptor 2 converges on MAPK/AP-1 signaling.46 Here, JUN is linked to acute myeloid leukemia.