Under pathological conditions such as nerve injury or neurodegenerative diseases, CNTF can promote the survival, differentiation, and regeneration of nerve cells, reduce neuroinflammatory responses, and maintain the stability of nerve function by activating its receptors and related signaling pathways (Cao et al., 2010; Do Rhee et al., 2022). The gene discussed is CNTF; the disease is neurodegenerative disease.