The biochemical diagnosis of MACS, evidenced by preoperative ACTH-independent hypercortisolism with elevated post-DST cortisol values, suppressed ACTH, and low DHEA-S, combined with profound postoperative hypocortisolism demonstrated by CST results, unequivocally confirms AHC and its surgical cure. The gene discussed is POMC; the disease is adrenal gland hyperfunction.