Collectively, these findings suggest that PPARα is a key regulator of LD-mitochondrial crosstalk and lipid metabolism, demonstrating that both systemic (fenofibrate) and nigral-targeted (GW7647) PPARα activation restore lipid homeostasis and mitigate nigrostriatal degeneration in CIH-aggravated PD models. This evidence concerns the gene PPARA and Parkinson disease.