Clinical evidence from a meta-analysis by Lin et al. (n = 391 HCC cases, 334 controls) established significant correlations between YAP overexpression and aggressive tumor characteristics: vascular invasion (OR = 2.21, 95% CI 1.64-2.97, P < 0.00001), poor cellular differentiation (OR = 2.38, 95% CI 1.61-3.51, P < 0.00001), tumor size > 5.00 cm (OR = 2.52, 95%CI 1.75-3.62, P < 0.00001), and advanced TNM staging (OR = 0.44 for I+II vs. III+IV, 95% CI 0.28-0.75, P = 0.00003) 44. Here, YAP1 is linked to neoplasm.