A similar protection against HFD-induced hepatic steatosis was also observed in mice ablated for TPH1 or 5-HT2B in adipocytes (adiponectin-cre; Tph1fl/fl or Htr2bfl/fl) or mice genetically deleted for the 5-HT3a receptor (Htr3a-/-) 225,228. This evidence concerns the gene TPH1 and fatty liver disease.