While the role of central 5-HT signaling in alcohol use disorders and associated mood dysregulations have been extensively investigated, showing that chronic alcohol consumption enhances brain 5-HT innervation and signaling, with 5-HT1A receptors playing a key role in binge-alcohol drinking behavior 294-301, little is known regarding the potential role of peripheral 5-HT signaling in ALD. This evidence concerns the gene HTR5A and alcohol abuse.