HTR1A and portal hypertension: 5-HT may not only modulate portal hypertension through the activity of 5-HT1A and 5-HT2A receptors 69,70,287,288, but could also regulate angiogenesis by modulating endothelial cells function through VEGF-dependent or -independent manners, involving various 5-HT receptors such as 5-HT1B, 5-HT2A, 5-HT4 or 5-HT7289-293.