It is important to note that regulation of CRL4ACRBN E3 ligase activity is highly complex, and how atherosclerosis-related stimuli mediate the nuclear-to-cytoplasmic translocation of CUL4A, DDB1, and CRBN, as well as whether additional mechanisms regulate the activity of the CRL4ACRBN complex, remains to be fully elucidated. The gene discussed is CRBN; the disease is atherosclerosis.