APOE and atherosclerosis: (2) We did not employ an endothelial-specific conditional KSR2 knockout mouse model in this study, but we utilized multiple in vivo models—including HFD ad libitum-fed KSR2−/− mice, pair-fed Apoe−/−KSR2−/− mice, and Apoe−/− mice with endothelial-specific KSR2 overexpression via AAV9-ICAM2 to exclude the confounding effects of metabolic abnormalities and to validate the protective role of endothelial KSR2 in atherosclerosis.