P4HA2 and breast carcinoma: We further found that P4HA2 knockdown can also exert a synergistic effect with radiotherapy - the combination of 4 Gy radiotherapy and P4HA2 knockdown significantly reduced the number of breast cancer cells, while almost eliminating these cells when combined with 6 Gy irradiation, which fully demonstrates knockdown of P4HA2 in enhancing radiosensitivity.