GSTM1 and neoplasm: Zhang et al. developed a self-reinforcing metabolic nanojammer, Hb/Mito-DCA@Cu/ZIF-8@HA (HMCZH), constructed from a copper-doped zeolite imidazole framework (ZIF-8) core co-loaded with oxygenated hemoglobin (Hb) and mitochondria-targeted dichloroacetate (Mito-DCA), and subsequently encapsulated in a HA layer for enhanced CD44-mediated tumor uptake 176.