Systematic studies by Bruce’s group using Cx3cr1-deficient AD murine models have highlighted the divergent roles of neuron-microglial fractalkine signaling in modulating Aβ and tau pathologies (Bhaskar et al., 2010; Lee et al., 2010; Lee et al., 2014; Maphis et al., 2015; Puntambekar et al., 2022). The gene discussed is CX3CR1; the disease is Alzheimer disease.