For example, the T2DM model rats established by high-fat diet combined with intraperitoneal injection of streptozotocin (30 mg/kg) were fed with R. alismatis polysaccharide for 6 weeks, the levels of SOD and GSH-Px in liver tissue of rats were decreased, and insulin resistance and lipid metabolism were improved (Zhang et al., 2018). Here, SOD1 is linked to type 2 diabetes mellitus.