CASP3 and Hand-foot syndrome: -Inhibited expression of Col I, Col III, and α-SMA (fibrosis markers)-Induced morphological changes and apoptosis in HFs-Arrested cell cycle at G0/G1 phase-Downregulated AKT phosphorylation (p-AKT)-Activated pro-apoptotic proteins Bax and cleaved Caspase-3-Suppressed anti-apoptotic Bcl-2 expression