-Inhibits the proliferation and migration of KFs more effectively than NFs.-Induces reversible cell-cycle arrest (not apoptosis).-Reduces collagen production significantly.-Suppresses phosphorylation of AKT, ERK1/2, and STAT3.-Strongly inhibits STAT3 phosphorylation, critical for collagen production, proliferation, and migration.-Reduces keloid nodule size and collagen accumulation in vivo.-Decreases VEGF expression, suppressing angiogenesis in keloid tissue. This evidence concerns the gene STAT3 and keloid.