-Inhibited pAkt-S473, p-mTOR, and downstream signaling-Reduced KF proliferation, attachment, migration, and invasion-Induced apoptosis selectively in KFs-Suppressed ECM proteins: collagen I, fibronectin, α-SMA-Caused shrinkage and apoptosis in keloid tissue-Depleted angiogenic markers (CD31, CD34). The gene discussed is FN1; the disease is keloid.