-Significantly reduced scar thickness, vascularity, and pliability-Decreased collagen volume fraction and scar elevation index-Suppressed CD31 expression, indicating reduced angiogenesis-Lowered levels of p-AKT, p70S6K, and p-p70S6K-No adverse effects such as allergy, erythema, erosion, or dyspigmentation were observed. This evidence concerns the gene PECAM1 and Allergy.