Indirect via TRIM family mapping to AKT/mTOR pathways (not TRIM54 itself yet demonstrated) (Dove Medical Press, BioMed Central), TRIM54 causes myofibrillar myopathy in humans when mutated; —Mutations cause myofibrillar myopathy; autosomal inheritance; TRIM54 linked to mitochondrial DNA maintenance defects (PubMed, GeneCards) Mitochondrial features altered in patient casesNo primary autoimmune role. This evidence concerns the gene TRAT1 and myofibrillar myopathy.