HRH2 and cardiovascular disorder: • Assess for mimickers and comorbidities for RLS (Gossard et al., 2021) common in the elderly: ◦ Peripheral neuropathy ◦ Parkinson's disease ◦ Renal Insufficiency ◦ Cardiovascular disease ◦ Cognitive decline • Consider common medications that can be associated with RLS: ◦ Neuroleptics ◦ SSRI/SNRI ◦ Anti-dopaminergic antiemetics ◦ Proton-pump inhibitors ◦ Histamine H2-receptor antagonists • Check serum basic metabolic panel and iron studies