However, in colorectal cancer eIF3f is overexpressed and has a tumor-driving function that is independent of translation and involves a deubiquitinase activity encoded by the MPN/MOV34 motif, eIF3f shares with other members of the JAB1/MPN/MOV34 metalloenzyme (JAMM) family of deubiquitinases (DUBs)19,20. The gene discussed is EIF3F; the disease is neoplasm.