Mechanistically, obesity-induced alterations in the adipose-tissue microenvironment and chronic low-grade inflammation can modulate adiponectin secretion and receptor dynamics66, while impaired receptor signaling or cleavage of T-cadherin reduces tissue sequestration and increases circulating levels, a process termed adiponectin resistance67. The gene discussed is CDH13; the disease is obesity due to melanocortin 4 receptor deficiency.