ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Collectively, the evidence from Woodward et al. 68, Blüher60, Aguilar-Salinas et al. 69, Kalkman67, Fuster et al. 68, Han et al. 71, and Ahl et al. 70 supports the interpretation that elevated adiponectin in obesity represents a physiological adaptation rather than a contradiction of prior literature.