To delineate the role of Kdm6b in macrophage-induced atherosclerosis, we generated macrophage-specific Kdm6b-knockout mice on an LDL receptor-deficient (Ldlr−/−) background and used Csf1r-cre to drive recombination in macrophages in Kdm6b-floxed mice. Here, KDM6B is linked to atherosclerosis.