In this study, our team conducted methylated RNA immunoprecipitation (RIP) sequencing (meRIP-seq) on granulocyte–macrophage colony-stimulating factor (GM-CSF)-treated monocytes and IFN-γ-stimulated macrophages to provide a comprehensive understanding of the dynamic role of m6A modification in macrophage activation and its contribution to atherosclerosis. This evidence concerns the gene IFNG and atherosclerosis.