Consistent with the ApcMin/+ model, Ythdf1cKi exacerbated colorectal tumorigenesis in terms of both tumor number (P = 0.015) and tumor load (P = 0.017) (Fig. 2j), with increased cell proliferation (P < 0.0001) and suppressed apoptosis (P = 0.0005), as determined by Ki67 and TUNEL staining (Fig. 2k). The gene discussed is MKI67; the disease is neoplasm.