Next, an LGR5 stem cell signature was derived via two independent microarray platforms, Affymetrix and Agilent.31 YTHDF1 expression in Cohort III was positively correlated with the full LGR5 stem cell expression signature across both platforms, suggesting that YTHDF1 expression is correlated with cancer stemness in human patients (Fig. 8d, Supplementary Fig. 5h). This evidence concerns the gene LGR5 and cancer.