To better mimic the role of CSCs in tumorigenesis and chemoresistance, we evaluated the oncogenic role of YTHDF1 by using Lgr5-specific Ythdf1 knock-in and knockout mouse models of CRC, leading to specific manipulation of YTHDF1 in LGR5-expressing lineage. The gene discussed is YTHDF1; the disease is colorectal carcinoma.