YTHDF1 and neoplasm: Multicellular tumor spheroids enriched with CSCs exhibit increased resistance to drug-induced apoptosis, a defining feature of chemoresistance.27 To explore the translational relevance of YTHDF1 in the CRC chemotherapy response, we investigated the effect of YTHDF1 manipulation on sensitivity to two first-line chemotherapeutic agents used in CRC, OXA and 5-FU.