At the protein level, YTHDF1 expression in TMA Cohort I was positively correlated with CD133 (χ2 = 26.26; P < 0.001) and LGR5 (χ2 = 37.62; P < 0.001) (Fig. 8b) expression in CRC tissues, whereas CD133 and LGR5 expression was also positively correlated (χ2 = 32.44; P < 0.001). The gene discussed is LGR5; the disease is colorectal carcinoma.