Here, we determined the number, density and islet-protective phenotype of pMSCs in situ in individuals with and without type 1 diabetes.<h4>Methods</h4>Multiplex immunohistochemistry was used to identify pMSCs (CD90<sup>+</sup>/CD105<sup>+</sup>/CD73<sup>+</sup>/CD31<sup>-</sup>/CD45<sup>-</sup>/CD34<sup>-</sup>) in human pancreas sections from 38 donors (Network for Pancreatic Organ Donors with Diabetes and Exeter Archival Diabetes Biobank). This evidence concerns the gene NT5E and type 1 diabetes mellitus.